MSC Virtuosa: 22-Night Grand Voyage

Palermo cruise port drops you into one of the most chaotic, layered, and rewarding cities in the Mediterranean. This is the capital of Sicily, sitting on the northwestern coast of the island along a gulf facing the Tyrrhenian Sea.

Naples cruise port is one of the most popular stops on Mediterranean itineraries, and it's easy to see why. The city sits on the Bay of Naples with Mount Vesuvius looming behind it, and it serves as the gateway to Pompeii, the Amalfi Coast, Capri, and Sorrento.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Malaga cruise port is the main gateway to Spain's Costa del Sol and Andalusia. The city sits on Spain's southern coast, about 130 kilometers west of Granada and 50 kilometers east of Marbella.

Santa Cruz de Tenerife is the capital of Tenerife, the largest of Spain's Canary Islands, located in the Atlantic Ocean about 300 km off the coast of Morocco. The cruise port sits in the heart of the city, directly adjacent to the commercial center and within walking distance of the main shopping street and waterfront.

Rio de Janeiro is one of the most visually dramatic cities on earth, set between granite peaks, tropical forest, and Atlantic beaches. The city of about 6.