Serenade of the Seas: 15-Night Panama Canal Eastward

San Diego is a major cruise port on the Southern California coast, about 120 miles south of Los Angeles and directly on the Mexican border. The B Street Cruise Ship Terminal and adjacent Broadway Pier sit in downtown San Diego along the Embarcadero waterfront, within walking distance of the Gaslamp Quarter, Seaport Village, and the USS Midway Museum.

Stretched along Banderas Bay with the Sierra Madre mountains rising directly behind the shoreline, Puerto Vallarta draws about 290,000 residents year-round and far more during the winter cruise season. The city has managed to grow as a tourist destination while keeping its Mexican identity intact, particularly in the Zona Romantica and the malecon (boardwalk) areas where local life and tourism coexist on the same streets.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.