16 Night Panama Canal Cruise
This 16-night Panama Canal cruise aboard the Nieuw Amsterdam by Holland America Line sails from San Diego to Fort Lauderdale (Port Everglades), departing October 2, 2026, calling at Puerto Vallarta, Huatulco, Puerto Chiapas, and 5 more ports, and returns October 18, 2026. Cabin prices start from $2,309 per person.
San Diego is a major cruise port on the Southern California coast, about 120 miles south of Los Angeles and directly on the Mexican border. The B Street Cruise Ship Terminal and adjacent Broadway Pier sit in downtown San Diego along the Embarcadero waterfront, within walking distance of the Gaslamp Quarter, Seaport Village, and the USS Midway Museum.
Read more →Stretched along Banderas Bay with the Sierra Madre mountains rising directly behind the shoreline, Puerto Vallarta draws about 290,000 residents year-round and far more during the winter cruise season. The city has managed to grow as a tourist destination while keeping its Mexican identity intact, particularly in the Zona Romantica and the malecon (boardwalk) areas where local life and tourism coexist on the same streets.
Read more →Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.
Read more →Half Moon Cay (officially renamed RelaxAway, Half Moon Cay in 2024) is Holland America Line's private Bahamian destination, also used by certain Carnival Cruise Line itineraries. The island sits in the southeast Bahamas, about 100 miles southeast of Nassau, in the Exuma chain.
Read more →Fort Lauderdale cruise port, officially Port Everglades, is one of the busiest cruise ports in the world and the closest major competitor to PortMiami, just 25 miles to the south. It sits on the southeastern coast of Florida across the cities of Fort Lauderdale, Hollywood, and Dania Beach.
Read more →Interior cabin
New to these charts? How to read cruise price history
Other Panama Canal departures
We may earn a commission when you book through this link, at no extra cost to you.
Track prices
Get emailed when double occupancy drops below your target.
We may earn a commission when you book through this link, at no extra cost to you.
