Seven Seas Splendor: 14-Night Panama Canal

Miami cruise port, officially called PortMiami, is the busiest cruise port in the world by passenger volume. Millions of people pass through here every year, and nearly every major cruise line uses it as a home port.

Cozumel cruise port is one of the busiest in the Caribbean, with multiple ships docking on the island every day during peak season. Cozumel is a flat, laid-back island off the eastern coast of Mexico's Yucatán Peninsula, and it's been a cruise staple for decades.

Costa Maya cruise port sits on the southern tip of Mexico's Caribbean coast, about 150 miles south of Cancun and close to the border with Belize. The port is not a city.

Roatan cruise port serves one of the Bay Islands of Honduras, a Caribbean destination famous for some of the best scuba diving in the Western Hemisphere. The island sits along the Mesoamerican Barrier Reef (the world's second-largest coral reef system) about 40 miles off the Honduras mainland.

Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.