Seven Seas Grandeur: 14-Night Panama Canal

Miami cruise port, officially called PortMiami, is the busiest cruise port in the world by passenger volume. Millions of people pass through here every year, and nearly every major cruise line uses it as a home port.

Costa Maya cruise port sits on the southern tip of Mexico's Caribbean coast, about 150 miles south of Cancun and close to the border with Belize. The port is not a city.

Roatan cruise port serves one of the Bay Islands of Honduras, a Caribbean destination famous for some of the best scuba diving in the Western Hemisphere. The island sits along the Mesoamerican Barrier Reef (the world's second-largest coral reef system) about 40 miles off the Honduras mainland.

Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Colon sits at the Atlantic (Caribbean) entrance to the Panama Canal, serving as the port of call for ships that transit the canal or stop before or after the crossing. The Colon 2000 cruise terminal and the nearby Cristobal pier handle the cruise traffic, both located away from the city center in secure port compounds.