Oceania Marina: 20-Night Panama Canal from Miami

Miami cruise port, officially called PortMiami, is the busiest cruise port in the world by passenger volume. Millions of people pass through here every year, and nearly every major cruise line uses it as a home port.

Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.

Aruba's capital sits just 15 miles off the Venezuelan coast, and it's one of the southern Caribbean's most popular cruise stops for good reason. Five berths across three air-conditioned terminals handle up to five ships at once, with water depths of 32 to 36 feet.

You've probably seen photos of Willemstad even if you don't realize it: that row of pastel-colored Dutch colonial buildings along the Handelskade is one of the most photographed waterfronts in the Caribbean. It's been a UNESCO World Heritage Site since 1997.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Costa Maya cruise port sits on the southern tip of Mexico's Caribbean coast, about 150 miles south of Cancun and close to the border with Belize. The port is not a city.

Cozumel cruise port is one of the busiest in the Caribbean, with multiple ships docking on the island every day during peak season. Cozumel is a flat, laid-back island off the eastern coast of Mexico's Yucatán Peninsula, and it's been a cruise staple for decades.