Costa Fascinosa: 7-Night Mediterranean from Toulon

Genoa cruise port is one of the main embarkation points for western Mediterranean itineraries, particularly for MSC and Costa Cruises, which both have roots here. The city is the capital of Liguria and the birthplace of Christopher Columbus, pesto, and focaccia, and it has a grittier, more working-class feel than the polished Italian cities most tourists flock to.

La Spezia is a working Italian naval and commercial city on the Ligurian coast, but cruise passengers know it primarily as the gateway to Cinque Terre, the five colorful fishing villages clinging to the cliffs along a rugged stretch of coastline just north of the city. The La Spezia cruise port sits at the edge of the city center, a short walk from the train station that connects directly to the Cinque Terre villages.

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Salerno is the eastern gateway to the Amalfi Coast, one of Italy's most celebrated stretches of coastline. Cruise ships dock at the Stazione Marittima in Salerno's port, a short walk from the city center and the starting point for trips along the legendary coastal road to Amalfi, Positano, and Ravello.

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.