Seabourn Ovation: 21-Night Mediterranean from Venice

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Seaside resort town on the French Riviera between Cannes and Saint-Tropez.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Built on a narrow strip of land between the Mediterranean and the Etang de Thau lagoon, Sete is a working fishing port of about 45,000 people on the Languedoc coast. The city calls itself the Venice of Languedoc for its network of canals, though the comparison undersells what makes Sete different: this is a genuine fishing town where trawlers unload the catch at the port each morning and the restaurants cook what came in that day.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.