MSC World Europa: 21-Night Transatlantic from Genoa

Genoa cruise port is one of the main embarkation points for western Mediterranean itineraries, particularly for MSC and Costa Cruises, which both have roots here. The city is the capital of Liguria and the birthplace of Christopher Columbus, pesto, and focaccia, and it has a grittier, more working-class feel than the polished Italian cities most tourists flock to.

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

La Spezia is a working Italian naval and commercial city on the Ligurian coast, but cruise passengers know it primarily as the gateway to Cinque Terre, the five colorful fishing villages clinging to the cliffs along a rugged stretch of coastline just north of the city. The La Spezia cruise port sits at the edge of the city center, a short walk from the train station that connects directly to the Cinque Terre villages.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Santa Cruz de Tenerife is the capital of Tenerife, the largest of Spain's Canary Islands, located in the Atlantic Ocean about 300 km off the coast of Morocco. The cruise port sits in the heart of the city, directly adjacent to the commercial center and within walking distance of the main shopping street and waterfront.

St. Maarten cruise port is one of the busiest in the Caribbean, with ships docking at the A.C.

Basseterre cruise port in St. Kitts uses the Port Zante terminal, a purpose-built cruise facility in the heart of Basseterre, the capital of St. Kitts and Nevis. Port Zante includes two dedicated cruise piers capable of berthing the largest modern ships plus a marina, restaurants, shops, and the Amina Craft Market.

Barbados cruise port is in Bridgetown, the capital of the easternmost Caribbean island. Bridgetown Port (Deep Water Harbour) sits just outside the city's UNESCO-listed historic center, with modern terminal facilities including 21 duty-free shops, restaurants, car rental agencies, and a tourism office.