Caribbean Princess: 21-Night Mediterranean from Rome (Civitavecchia)

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Cagliari is the capital of Sardinia, Italy's second-largest island, on the island's southern coast. The cruise port (Porto di Cagliari) sits directly at the edge of the old town, about a 10-minute walk from Piazza Matteotti and the base of the historic Castello district.

Palermo cruise port drops you into one of the most chaotic, layered, and rewarding cities in the Mediterranean. This is the capital of Sicily, sitting on the northwestern coast of the island along a gulf facing the Tyrrhenian Sea.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Mykonos cruise port is one of the most instantly recognizable stops in the Greek islands. Whitewashed cube buildings cascade down hills to the Aegean Sea, blue-domed churches punctuate the skyline, and windmills stand sentinel on the ridge above Mykonos Town (Chora).

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.

Rhodes is the largest of Greece's Dodecanese islands, sitting in the far southeastern Aegean Sea just 18 kilometers from the Turkish coast. The Rhodes cruise port is in the city of Rhodes on the island's northern tip, where ships dock right next to one of the best-preserved medieval old towns in Europe.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Mykonos cruise port is one of the most instantly recognizable stops in the Greek islands. Whitewashed cube buildings cascade down hills to the Aegean Sea, blue-domed churches punctuate the skyline, and windmills stand sentinel on the ridge above Mykonos Town (Chora).

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Katakolon is a small fishing village on the western coast of the Peloponnese, with a permanent population of only about 700 people. It exists on cruise maps for one reason: ancient Olympia, the birthplace of the Olympic Games, is 45 minutes inland.

Dubrovnik cruise port is the southern gateway to Croatia's Adriatic coast and one of the most visually striking stops in the Mediterranean. Ships dock at Port Gruž, about 3 kilometers northwest of the Old Town, with the walled medieval city perched on a rocky peninsula jutting into the sea.

Kotor cruise port is one of the most visually spectacular arrivals in the Adriatic. Ships sail through a deep fjord-like bay (Boka Kotorska) surrounded by limestone mountains that rise steeply from the water, with the walled medieval town of Kotor tucked at the base.

Naples cruise port is one of the most popular stops on Mediterranean itineraries, and it's easy to see why. The city sits on the Bay of Naples with Mount Vesuvius looming behind it, and it serves as the gateway to Pompeii, the Amalfi Coast, Capri, and Sorrento.