15-Night Panama Canal from Fort Lauderdale (Port Everglades)

Fort Lauderdale cruise port, officially Port Everglades, is one of the busiest cruise ports in the world and the closest major competitor to PortMiami, just 25 miles to the south. It sits on the southeastern coast of Florida across the cities of Fort Lauderdale, Hollywood, and Dania Beach.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Stretched along Banderas Bay with the Sierra Madre mountains rising directly behind the shoreline, Puerto Vallarta draws about 290,000 residents year-round and far more during the winter cruise season. The city has managed to grow as a tourist destination while keeping its Mexican identity intact, particularly in the Zona Romantica and the malecon (boardwalk) areas where local life and tourism coexist on the same streets.