21-Night Mediterranean from Barcelona

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Nice is the capital of the French Riviera, a Mediterranean city of about 340,000 people wedged between the Maritime Alps and the Cote d'Azur coastline. Cruise ships anchor in the bay at Villefranche-sur-Mer, a small harbor town about 6 km east of Nice, or occasionally dock at Nice's own port.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Naples cruise port is one of the most popular stops on Mediterranean itineraries, and it's easy to see why. The city sits on the Bay of Naples with Mount Vesuvius looming behind it, and it serves as the gateway to Pompeii, the Amalfi Coast, Capri, and Sorrento.

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.

Istanbul cruise port is one of the most extraordinary arrivals in the world. Ships sail up the Bosphorus Strait between Europe and Asia, past Ottoman palaces and Byzantine ruins, and dock at Galataport, the underground cruise terminal in the Karaköy neighborhood right in the center of the city.

Mykonos cruise port is one of the most instantly recognizable stops in the Greek islands. Whitewashed cube buildings cascade down hills to the Aegean Sea, blue-domed churches punctuate the skyline, and windmills stand sentinel on the ridge above Mykonos Town (Chora).

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Katakolon is a small fishing village on the western coast of the Peloponnese, with a permanent population of only about 700 people. It exists on cruise maps for one reason: ancient Olympia, the birthplace of the Olympic Games, is 45 minutes inland.

Dubrovnik cruise port is the southern gateway to Croatia's Adriatic coast and one of the most visually striking stops in the Mediterranean. Ships dock at Port Gruž, about 3 kilometers northwest of the Old Town, with the walled medieval city perched on a rocky peninsula jutting into the sea.