Rotterdam: 20-Night Mediterranean from Rotterdam

Rotterdam is Europe's largest port city and a major cruise embarkation point in the Netherlands, located in the Rhine-Meuse-Scheldt river delta about 80 km south of Amsterdam. The cruise terminal (Rotterdam Cruise Terminal) is at the Wilhelminakade on the south bank of the Nieuwe Maas river, in the shadow of the Erasmus Bridge.

Zeebrugge is a North Sea port about 15 km from Bruges, one of Europe's best-preserved medieval cities. Ships dock at Zeebrugge, but the destination is Bruges: a city of 120,000 people whose medieval center survived the centuries virtually intact because the city's commercial importance faded after the Zwin river silted up in the 15th century, and nobody had a reason to tear anything down.

Porto is Portugal's second city, sitting on the steep banks of the Douro River near the Atlantic coast. Cruise ships dock at the port of Leixoes, an industrial harbor in the suburb of Matosinhos about 8 kilometers north of Porto's historic center.

Lisbon cruise port is one of the most atmospheric arrivals in Europe. Ships sail up the Tagus River past the 25 de Abril Bridge (a near-twin of San Francisco's Golden Gate) and the Christ the King statue, with the city rising up on seven hills to the north.

Cadiz is the actual cruise port marketed as "Seville (Cadiz)" by cruise lines because Seville, Spain's fourth-largest city, is the primary day-trip draw from this port. Cadiz itself is one of Europe's oldest continuously inhabited cities, perched on a narrow peninsula jutting into the Atlantic on Spain's southwestern coast.

Gibraltar is a British Overseas Territory at the southern tip of the Iberian Peninsula, a 6.7-square-kilometer enclave dominated by the Rock of Gibraltar, a 426-meter limestone monolith that guards the western entrance to the Mediterranean.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Palma de Mallorca cruise port is one of the busiest in the Mediterranean and the main cruise gateway to the Balearic Islands. Palma sits on the south coast of Mallorca, the largest of the Balearics, about 250 kilometers south of Barcelona.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.

Naples cruise port is one of the most popular stops on Mediterranean itineraries, and it's easy to see why. The city sits on the Bay of Naples with Mount Vesuvius looming behind it, and it serves as the gateway to Pompeii, the Amalfi Coast, Capri, and Sorrento.