Nieuw Statendam: 21-Night Mediterranean from Rome (Civitavecchia)

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Genoa cruise port is one of the main embarkation points for western Mediterranean itineraries, particularly for MSC and Costa Cruises, which both have roots here. The city is the capital of Liguria and the birthplace of Christopher Columbus, pesto, and focaccia, and it has a grittier, more working-class feel than the polished Italian cities most tourists flock to.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Gibraltar is a British Overseas Territory at the southern tip of the Iberian Peninsula, a 6.7-square-kilometer enclave dominated by the Rock of Gibraltar, a 426-meter limestone monolith that guards the western entrance to the Mediterranean.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Alicante is a mid-sized Spanish city of about 330,000 people on the Costa Blanca in southeastern Spain. It's a working Mediterranean city that happens to have a beautiful waterfront, a hilltop castle, and some of the best weather in Europe.

La Goulette is the cruise port serving Tunis, Tunisia's capital, located on the Mediterranean coast of North Africa about 12 kilometers northeast of the city center. The port sits at the entrance to the Lake of Tunis, a shallow lagoon separating La Goulette from downtown.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Santorini cruise port is one of the most visually striking arrivals in cruising. Ships anchor in the flooded caldera of a volcanic crater, with the whitewashed villages of Fira and Oia perched dramatically 1,000 feet above on the cliff edge.

Rhodes is the largest of Greece's Dodecanese islands, sitting in the far southeastern Aegean Sea just 18 kilometers from the Turkish coast. The Rhodes cruise port is in the city of Rhodes on the island's northern tip, where ships dock right next to one of the best-preserved medieval old towns in Europe.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.