25-Night Panama Canal from Miami

Miami cruise port, officially called PortMiami, is the busiest cruise port in the world by passenger volume. Millions of people pass through here every year, and nearly every major cruise line uses it as a home port.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Colon sits at the Atlantic (Caribbean) entrance to the Panama Canal, serving as the port of call for ships that transit the canal or stop before or after the crossing. The Colon 2000 cruise terminal and the nearby Cristobal pier handle the cruise traffic, both located away from the city center in secure port compounds.

Cabo San Lucas sits at the very tip of Mexico's Baja California Peninsula, where the Pacific Ocean meets the Sea of Cortez. This is a tender port: ships anchor in Cabo San Lucas Bay and passengers ride small boats to the marina.

San Diego is a major cruise port on the Southern California coast, about 120 miles south of Los Angeles and directly on the Mexican border. The B Street Cruise Ship Terminal and adjacent Broadway Pier sit in downtown San Diego along the Embarcadero waterfront, within walking distance of the Gaslamp Quarter, Seaport Village, and the USS Midway Museum.

Los Angeles cruise port is in San Pedro, a harbor neighborhood at the southern tip of the city, about 25 miles from downtown LA and 18 miles from LAX. The port is called the World Cruise Center, and it's the main departure point for Mexican Riviera, Hawaii, and Pacific Coast itineraries.

Seattle cruise port is the primary departure point for Alaska cruises out of the United States, with ships running the Inside Passage route from late April through early October. The city has two cruise terminals about three miles apart on the downtown waterfront.

Ketchikan cruise port is the first major stop on most Alaska Inside Passage itineraries coming up from Seattle or Vancouver. The town sits on Revillagigedo Island in Alaska's southernmost panhandle, wedged between the ocean and steep forested mountains.

Icy Strait Point is a privately developed cruise destination adjacent to Hoonah, a Tlingit village of about 800 people on the northern shore of Chichagof Island. Unlike most Alaska ports, this is a purpose-built cruise facility operated by Huna Totem Corporation, the local Tlingit Alaska Native corporation, meaning tourism revenue stays in the indigenous community.

Victoria is British Columbia's capital city, situated on the southern tip of Vancouver Island. It serves as a regular port of call on Alaska cruise itineraries departing from Seattle, typically as the first or last stop before or after the Inside Passage.