45-Night World Cruise from Rome (Civitavecchia)

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Salerno is the eastern gateway to the Amalfi Coast, one of Italy's most celebrated stretches of coastline. Cruise ships dock at the Stazione Marittima in Salerno's port, a short walk from the city center and the starting point for trips along the legendary coastal road to Amalfi, Positano, and Ravello.

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

La Goulette is the cruise port serving Tunis, Tunisia's capital, located on the Mediterranean coast of North Africa about 12 kilometers northeast of the city center. The port sits at the entrance to the Lake of Tunis, a shallow lagoon separating La Goulette from downtown.

Cagliari is the capital of Sardinia, Italy's second-largest island, on the island's southern coast. The cruise port (Porto di Cagliari) sits directly at the edge of the old town, about a 10-minute walk from Piazza Matteotti and the base of the historic Castello district.

Alicante is a mid-sized Spanish city of about 330,000 people on the Costa Blanca in southeastern Spain. It's a working Mediterranean city that happens to have a beautiful waterfront, a hilltop castle, and some of the best weather in Europe.

Cartagena is a historic port city of about 215,000 people on Spain's southeastern Mediterranean coast, in the Murcia region. Founded by the Carthaginians in 227 BC (as Carthago Nova), the city has been contested by Carthaginians, Romans, Moors, and Spanish kingdoms, and its layered history shows in the archaeological sites scattered through the compact center.

Malaga cruise port is the main gateway to Spain's Costa del Sol and Andalusia. The city sits on Spain's southern coast, about 130 kilometers west of Granada and 50 kilometers east of Marbella.

Cadiz is the actual cruise port marketed as "Seville (Cadiz)" by cruise lines because Seville, Spain's fourth-largest city, is the primary day-trip draw from this port. Cadiz itself is one of Europe's oldest continuously inhabited cities, perched on a narrow peninsula jutting into the Atlantic on Spain's southwestern coast.

Lisbon cruise port is one of the most atmospheric arrivals in Europe. Ships sail up the Tagus River past the 25 de Abril Bridge (a near-twin of San Francisco's Golden Gate) and the Christ the King statue, with the city rising up on seven hills to the north.

Funchal is the capital of Madeira, a Portuguese island in the Atlantic Ocean about 600 miles southwest of Lisbon and 400 miles north of the Canary Islands. The island is volcanic, mountainous, and green, with a subtropical climate that keeps temperatures mild year-round.

Santa Cruz de Tenerife is the capital of Tenerife, the largest of Spain's Canary Islands, located in the Atlantic Ocean about 300 km off the coast of Morocco. The cruise port sits in the heart of the city, directly adjacent to the commercial center and within walking distance of the main shopping street and waterfront.

San Juan cruise port is one of the busiest in the Caribbean and one of the few that doubles as both a major embarkation point and a popular port of call. The port sits in Old San Juan, the historic colonial core of Puerto Rico's capital, founded by Spanish colonists in 1521.

Miami cruise port, officially called PortMiami, is the busiest cruise port in the world by passenger volume. Millions of people pass through here every year, and nearly every major cruise line uses it as a home port.

Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.

Cartagena de Indias is a Caribbean port city of about 1 million people on Colombia's northern coast, and one of the best-preserved colonial cities in the Americas. The walled old city (Ciudad Amurallada) is a UNESCO World Heritage Site, built by the Spanish starting in the 16th century to protect the gold and silver being shipped back to Europe.

Stretched along Banderas Bay with the Sierra Madre mountains rising directly behind the shoreline, Puerto Vallarta draws about 290,000 residents year-round and far more during the winter cruise season. The city has managed to grow as a tourist destination while keeping its Mexican identity intact, particularly in the Zona Romantica and the malecon (boardwalk) areas where local life and tourism coexist on the same streets.