Enchanted Princess: 21-Night Mediterranean from Rome (Civitavecchia)

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Genoa cruise port is one of the main embarkation points for western Mediterranean itineraries, particularly for MSC and Costa Cruises, which both have roots here. The city is the capital of Liguria and the birthplace of Christopher Columbus, pesto, and focaccia, and it has a grittier, more working-class feel than the polished Italian cities most tourists flock to.

Palermo cruise port drops you into one of the most chaotic, layered, and rewarding cities in the Mediterranean. This is the capital of Sicily, sitting on the northwestern coast of the island along a gulf facing the Tyrrhenian Sea.

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.

Corfu cruise port is one of the most visited stops on Eastern Mediterranean and Greek Islands itineraries. The island sits off Greece's northwestern coast, just a short ferry ride from the southern tip of Albania, and has a distinct cultural identity shaped by centuries of Venetian, French, and British rule rather than the Ottoman history that dominates other Greek islands.

Kotor cruise port is one of the most visually spectacular arrivals in the Adriatic. Ships sail through a deep fjord-like bay (Boka Kotorska) surrounded by limestone mountains that rise steeply from the water, with the walled medieval town of Kotor tucked at the base.

Dubrovnik cruise port is the southern gateway to Croatia's Adriatic coast and one of the most visually striking stops in the Mediterranean. Ships dock at Port Gruž, about 3 kilometers northwest of the Old Town, with the walled medieval city perched on a rocky peninsula jutting into the sea.

Split cruise port is the main gateway to central Dalmatia and one of the most remarkable cities in Croatia. The city is built around and inside Diocletian's Palace, a 1,700-year-old Roman fortress that the emperor built as his retirement residence around 300 AD.

Trieste sits at the northeastern corner of Italy, pressed against the Slovenian border at the head of the Adriatic Sea. The city has about 200,000 residents and a distinctly Central European character that sets it apart from other Italian cruise ports.

Split cruise port is the main gateway to central Dalmatia and one of the most remarkable cities in Croatia. The city is built around and inside Diocletian's Palace, a 1,700-year-old Roman fortress that the emperor built as his retirement residence around 300 AD.

Kotor cruise port is one of the most visually spectacular arrivals in the Adriatic. Ships sail through a deep fjord-like bay (Boka Kotorska) surrounded by limestone mountains that rise steeply from the water, with the walled medieval town of Kotor tucked at the base.

Corfu cruise port is one of the most visited stops on Eastern Mediterranean and Greek Islands itineraries. The island sits off Greece's northwestern coast, just a short ferry ride from the southern tip of Albania, and has a distinct cultural identity shaped by centuries of Venetian, French, and British rule rather than the Ottoman history that dominates other Greek islands.

Katakolon is a small fishing village on the western coast of the Peloponnese, with a permanent population of only about 700 people. It exists on cruise maps for one reason: ancient Olympia, the birthplace of the Olympic Games, is 45 minutes inland.

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Mykonos cruise port is one of the most instantly recognizable stops in the Greek islands. Whitewashed cube buildings cascade down hills to the Aegean Sea, blue-domed churches punctuate the skyline, and windmills stand sentinel on the ridge above Mykonos Town (Chora).

Rhodes is the largest of Greece's Dodecanese islands, sitting in the far southeastern Aegean Sea just 18 kilometers from the Turkish coast. The Rhodes cruise port is in the city of Rhodes on the island's northern tip, where ships dock right next to one of the best-preserved medieval old towns in Europe.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.