21 Night Iconic Mediterranean Treasures

Istanbul cruise port is one of the most extraordinary arrivals in the world. Ships sail up the Bosphorus Strait between Europe and Asia, past Ottoman palaces and Byzantine ruins, and dock at Galataport, the underground cruise terminal in the Karaköy neighborhood right in the center of the city.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.

Rhodes is the largest of Greece's Dodecanese islands, sitting in the far southeastern Aegean Sea just 18 kilometers from the Turkish coast. The Rhodes cruise port is in the city of Rhodes on the island's northern tip, where ships dock right next to one of the best-preserved medieval old towns in Europe.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Kusadasi cruise port is Turkey's busiest and the primary gateway to Ephesus, one of the most significant ancient Greek and Roman cities in the world. The port sits on Turkey's central Aegean coast, about 95 kilometers south of Izmir, with ships docking at the Ege Ports cruise terminal right in the middle of town.

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.

Naples cruise port is one of the most popular stops on Mediterranean itineraries, and it's easy to see why. The city sits on the Bay of Naples with Mount Vesuvius looming behind it, and it serves as the gateway to Pompeii, the Amalfi Coast, Capri, and Sorrento.

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Nice is the capital of the French Riviera, a Mediterranean city of about 340,000 people wedged between the Maritime Alps and the Cote d'Azur coastline. Cruise ships anchor in the bay at Villefranche-sur-Mer, a small harbor town about 6 km east of Nice, or occasionally dock at Nice's own port.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Built on a narrow strip of land between the Mediterranean and the Etang de Thau lagoon, Sete is a working fishing port of about 45,000 people on the Languedoc coast. The city calls itself the Venice of Languedoc for its network of canals, though the comparison undersells what makes Sete different: this is a genuine fishing town where trawlers unload the catch at the port each morning and the restaurants cook what came in that day.