21-Night Mediterranean from Rome (Civitavecchia)

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

Kotor cruise port is one of the most visually spectacular arrivals in the Adriatic. Ships sail through a deep fjord-like bay (Boka Kotorska) surrounded by limestone mountains that rise steeply from the water, with the walled medieval town of Kotor tucked at the base.

Split cruise port is the main gateway to central Dalmatia and one of the most remarkable cities in Croatia. The city is built around and inside Diocletian's Palace, a 1,700-year-old Roman fortress that the emperor built as his retirement residence around 300 AD.

Dubrovnik cruise port is the southern gateway to Croatia's Adriatic coast and one of the most visually striking stops in the Mediterranean. Ships dock at Port Gruž, about 3 kilometers northwest of the Old Town, with the walled medieval city perched on a rocky peninsula jutting into the sea.

Souda Bay is the deep-water port serving Chania, the second-largest city on Crete and arguably the most beautiful town in all of Greece. Cruise ships dock at Souda, a small port town about 7 km east of Chania's historic center.

Istanbul cruise port is one of the most extraordinary arrivals in the world. Ships sail up the Bosphorus Strait between Europe and Asia, past Ottoman palaces and Byzantine ruins, and dock at Galataport, the underground cruise terminal in the Karaköy neighborhood right in the center of the city.