Oosterdam: 16-Night South America
This 16-night Panama Canal cruise aboard the Oosterdam by Holland America Line sails from Fort Lauderdale (Port Everglades) to Santiago (San Antonio), departing November 18, 2026, calling at Grand Cayman (George Town), Panama Canal, Panama City (Fuerte Amador), and 4 more ports, and returns December 4, 2026. Cabin prices start from $1,899 per person.
Fort Lauderdale cruise port, officially Port Everglades, is one of the busiest cruise ports in the world and the closest major competitor to PortMiami, just 25 miles to the south. It sits on the southeastern coast of Florida across the cities of Fort Lauderdale, Hollywood, and Dania Beach.
Read more →Grand Cayman is the largest of the three Cayman Islands, a British Overseas Territory in the western Caribbean known for Seven Mile Beach, exceptional diving, and its role as a major offshore financial center. George Town serves as the cruise port, but there's no pier large enough for cruise ships.
Read more →Interior cabin
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Questions about this sailing
How much does this cruise cost per night?
Interior cabins start at $1,899 per person for the 16 nights, about $119 a night, with taxes and port fees included.
Is $1,899 a good price for this sailing?
It is $150 above the lowest interior price we have recorded for this sailing since March 9, 2026 ($1,749 on September 2, 2026).
Which ports does it visit?
It sails from Fort Lauderdale (Port Everglades) to Santiago (San Antonio) and calls at Grand Cayman (George Town), Panama Canal, Panama City (Fuerte Amador), Manta, Trujillo (Salaverry), Lima (Callao) and La Serena (Coquimbo), with 6 days at sea.
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