Costa Serena: 15-Night Eastern Mediterranean

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

Savona cruise port is the main homeport for Costa Crociere (Costa Cruises), Italy's largest cruise line. Savona sits on the Italian Riviera (Liguria region) about 45 kilometers southwest of Genoa and 170 kilometers north of Nice.

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

Ibiza is one of Spain's Balearic Islands in the western Mediterranean, about 150 km off the coast of Valencia. The cruise port is in Ibiza Town (Eivissa), on the southeast coast of the island.

Palma de Mallorca cruise port is one of the busiest in the Mediterranean and the main cruise gateway to the Balearic Islands. Palma sits on the south coast of Mallorca, the largest of the Balearics, about 250 kilometers south of Barcelona.

Valletta cruise port is one of the most visually dramatic arrivals on any Mediterranean itinerary. Ships sail into the Grand Harbour, a deep natural inlet flanked by honey-colored limestone walls that rise straight out of the water, with Valletta itself perched on the peninsula above.

Athens cruise port is in Piraeus, a busy port city about 10 kilometers southwest of central Athens. Piraeus is its own city, not just a terminal, and it handles cruise ships, island ferries, and commercial traffic all at once.

Santorini cruise port is one of the most visually striking arrivals in cruising. Ships anchor in the flooded caldera of a volcanic crater, with the whitewashed villages of Fira and Oia perched dramatically 1,000 feet above on the cliff edge.

Mykonos cruise port is one of the most instantly recognizable stops in the Greek islands. Whitewashed cube buildings cascade down hills to the Aegean Sea, blue-domed churches punctuate the skyline, and windmills stand sentinel on the ridge above Mykonos Town (Chora).

Messina cruise port sits at the northeastern tip of Sicily, directly across the narrow Strait of Messina from mainland Italy. Ships dock right at the city waterfront, making it one of the easiest Mediterranean ports to step off and explore.