25 Night Grand Voyage Cruise

MSC Opera

This 25-night Caribbean (Eastern) cruise aboard the MSC Opera by MSC Cruises sails from Rome (Civitavecchia) to La Romana, departing October 29, 2026, calling at Genoa, Florence (Livorno), Marseille, and 11 more ports, and returns November 23, 2026. Cabin prices start from $4,807 per person.

Days
25 nights
Departs
Oct 29, 2026
Ports
15
Returns
Nov 23, 2026
Sea days
10
Distance
6,160nm
Itinerary
Embark Port Sea
Day 1
Oct 29
Embark
Rome (Civitavecchia), Italy
dep 19:00

Rome's cruise port is in Civitavecchia, a working port town about 80 kilometers northwest of the city. That distance is the single most important thing to understand about this stop.

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Day 2
Oct 30
Genoa, Italy
arr 08:00 · dep 18:00

Genoa cruise port is one of the main embarkation points for western Mediterranean itineraries, particularly for MSC and Costa Cruises, which both have roots here. The city is the capital of Liguria and the birthplace of Christopher Columbus, pesto, and focaccia, and it has a grittier, more working-class feel than the polished Italian cities most tourists flock to.

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Day 3
Oct 31
Florence (Livorno), Italy
arr 08:00 · dep 18:00

Florence (Livorno) cruise port is the main Tuscan stop on Mediterranean itineraries, but it's worth being clear about what you're actually docking at. The port is Livorno, a working industrial city on the Ligurian coast, about 85 kilometers west of Florence.

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Day 4
Nov 1
Marseille, France
arr 09:00 · dep 18:00

Marseille cruise port is France's busiest and one of the major stops on western Mediterranean itineraries. The city is France's second largest and its oldest, founded by Greek sailors over 2,600 years ago, and it has a rougher, more authentic edge than the polished Riviera towns further east.

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Day 5
Nov 2
Barcelona, Spain
arr 07:00 · dep 16:00

Barcelona cruise port is the busiest in the Mediterranean, handling millions of passengers a year across multiple terminals. The city behind it earns that traffic.

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Day 6
Nov 3
At Sea
Day 7
Nov 4
Tangier, Morocco
arr 08:00 · dep 17:00

Tangier sits at the northwestern tip of Africa, where the Mediterranean meets the Atlantic and Morocco looks across the Strait of Gibraltar at Spain, just 14 km away. The city has about 1.

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Day 8
Nov 5
At Sea
Day 9
Nov 6
At Sea
Day 10
Nov 7
At Sea
Day 11
Nov 8
At Sea
Day 12
Nov 9
At Sea
Day 13
Nov 10
At Sea
Day 14
Nov 11
At Sea
Day 15
Nov 12
Antigua (St. John's)
arr 09:00 · dep 18:00

St. John's is the capital and main cruise port of Antigua, one of the Leeward Islands in the eastern Caribbean. The Heritage Quay and Redcliffe Quay cruise terminals sit in the heart of St. John's, directly adjacent to the duty-free shopping district.

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Day 16
Nov 13
St. Maarten (Philipsburg)
arr 09:00 · dep 18:00

St. Maarten cruise port is one of the busiest in the Caribbean, with ships docking at the A.C.

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Day 17
Nov 14
Basseterre St Kitts, Port Zante
arr 08:00 · dep 18:00

Basseterre cruise port in St. Kitts uses the Port Zante terminal, a purpose-built cruise facility in the heart of Basseterre, the capital of St. Kitts and Nevis. Port Zante includes two dedicated cruise piers capable of berthing the largest modern ships plus a marina, restaurants, shops, and the Amina Craft Market.

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Day 18
Nov 15
At Sea
Day 19
Nov 16
La Romana, Dominican Republic
arr 07:00 · dep 23:30

Most cruise passengers arriving at La Romana are headed somewhere else - Casa de Campo, the Caribbean's most exclusive resort complex, or Altos de Chavon, a replica Mediterranean village perched on a cliff above the Chavon River. Cruise ships dock at the Central Romana port, about a 10-minute drive from the Casa de Campo resort area.

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Day 20
Nov 17
Catalina Island, Dominican Republic
arr 07:00 · dep 17:00
Day 21
Nov 18
At Sea
Day 22
Nov 19
Barbados
arr 09:00 · dep 19:00

Barbados cruise port is in Bridgetown, the capital of the easternmost Caribbean island. Bridgetown Port (Deep Water Harbour) sits just outside the city's UNESCO-listed historic center, with modern terminal facilities including 21 duty-free shops, restaurants, car rental agencies, and a tourism office.

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Day 23
Nov 20
Fort-de-France, Martinique
arr 08:00 · dep 19:00

Martinique gives you something most Caribbean ports can't: an actual piece of France in the tropics. This is a French overseas department, so the bakeries are real, the wine is good, and the Creole cuisine draws from both metropolitan French technique and Caribbean soul.

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Day 24
Nov 21
Pointe-a-Pitre, Guadeloupe
arr 07:00 · dep 16:00

Pointe-a-Pitre is the economic capital of Guadeloupe, a French overseas department in the Lesser Antilles that gives you Caribbean beaches with French culture, cuisine, and infrastructure. The archipelago consists of two main islands shaped like a butterfly: Grande-Terre (flat, with beaches and sugar cane) and Basse-Terre (mountainous, with rainforest and a live volcano).

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Day 25
Nov 22
Tortola Island BVI, Road Town, UK Virgin Islands
arr 07:30 · dep 15:30

Tortola is the largest of the British Virgin Islands, a mountainous, lush Caribbean island where Road Town serves as the capital of this British Overseas Territory. The cruise port at Road Town Pier Park handles two large ships simultaneously (up to 180,000 GT).

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Day 26
Nov 23
Disembark
La Romana, Dominican Republic
arr 09:00

Most cruise passengers arriving at La Romana are headed somewhere else - Casa de Campo, the Caribbean's most exclusive resort complex, or Altos de Chavon, a replica Mediterranean village perched on a cliff above the Chavon River. Cruise ships dock at the Central Romana port, about a 10-minute drive from the Casa de Campo resort area.

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Loading map...
1Embark/Debark3Port of CallRoute
Distance
≈ 6,160nm
At sea
10 of 25 nights
Type
One-way
Price history

Interior cabin

$1,577last available Sep 15
Low
$1,168
High
$2,055
Average
$1,652
$1,079$1,345$1,612$1,878$2,144Mar 9Jun 12Sep 15$1,913 · Mar 9$2,055 · Mar 11$1,685 · Mar 25$2,055 · Apr 19$1,584 · Apr 25$1,954 · Apr 29$1,584 · May 14$1,411 · Jun 13$1,168 · Jun 21$1,225 · Jun 25$2,000 · Aug 22$1,630 · Sep 9$1,365 · Sep 10$1,577 · Sep 14$1,577 · Sep 15

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Starting from
$4,807/person
Incl. taxes & port fees
Checked today · Sep 28
Last change Sep 14: $1,365 → $1,577 (+$212)
Interior
Last seen Sep 15
$1,577
Ocean View
Last seen Sep 23
$2,127
Balcony
Last seen Jun 7
$3,631
Spa
$192/night
$4,807
Suite
Last seen Aug 13
$5,855

Track prices

Get emailed when double occupancy drops below your target.

MSC Opera
Your ship
MSC Opera
MSC Cruises · Lirica class · Built 2004
Passengers
2,150
Tonnage
65,591
Length
275m
Crew
728
Onboard
PoolHot TubWater ParkSpaSaunaSteam RoomThermal SuiteHair SalonFitness CenterJogging TrackMini GolfVideo Arcade
Full ship profile →
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